TLR-based immune adjuvants
نویسندگان
چکیده
منابع مشابه
Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates.
TLR ligands (TLR-Ls) represent novel vaccine adjuvants, but their immunologic effects in humans remain poorly defined in vivo. In the present study, we analyzed the innate responses stimulated by different TLR-Ls in rhesus macaques. MPL (TLR4-L), R-848 (TLR7/8-L), or cytosine-phosphate-guanine oligodeoxynucleotide (TLR9-L) induced a rapid and robust expansion of blood neutrophils, with a concom...
متن کاملDistinct TLR adjuvants differentially stimulate systemic and local innate immune responses in non-human primates Authors
Toll-like receptor ligands (TLR-L) represent novel vaccine adjuvants, but their immunological effects in humans in-vivo remain poorly defined. Here we analyzed the innate responses stimulated by different TLR-L in rhesus macaques, a relevant preclinical model for vaccine testing. MPL (TLR4-L), R-848 (TLR7/8-L) or CpG-ODN (TLR9-L) induced rapid (3hr) and robust (>92% of WBC) expansion of blood n...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2011
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2010.08.002